Preliminary estimates indicate that the number of preventable deaths in the United States increased 1.2% in 2022 to 227,664, an all-time high. A 1.9% increase in drug overdose deaths helped drive this record high. A total of 100,105 people died from drug overdoses in 2022, also an all-time high. However, the 1.9% increase in 2022 is substantially lower than in the last several years, 2021 experienced a 17.6% increase while 2020 experienced a 34.4% increase.